Author | Adjuvant systemic treatment regimen | Surgical technique and additional treatments |
Yu et al. [2] | Post-operative course of oral alendronate 10 mg/day pulsed for two months with 1-month intervals and continued for 2 years. | High-speed burr for aggressive curettage, exposed cortical bone was burned with electric knife, cavity filling with bone cement, and internal fixation. |
Xu et al. [1] | IV zoledronic acid 4 mg (n = 26) or IV incadronate disodium 10 mg (n = 11) dosed once preoperatively and one dose every month post-operatively for 2 years. | En bloc total spondylectomy (n = 36) v. subtotal resection (n = 66). Additionally treatments included preoperative selective artery embolization (n = 37), local treatment with cisplatin (n = 35) or methotrexate (n = 29), and adjuvant radiotherapy (n = 66). |
Tse et al. [4] | Pre-operatively 2 doses of IV palmidronate 90 mg (n = 7) or IV zolendronic acid 4 mg IV (n = 17) at intervals of 3 - 4 weeks. Post-operatively 3 more doses of IV bisphosphonates at 3 - 4 week intervals as well as oral clodronate for 3 months. | Lesions underwent wide excision if subchondral bone was destroyed or intralesional curettage with subsequent reconstruction or bone cementation. |
Cheng et al. [3] | Prior to surgery patients completed weekly doses of IV pamidronate 90 mg for 6 weeks. | Surgical curettage of tumor site was performed in all patients. |